In a town named Sugiyoshi, lives a puppy named Puku Puku, owned by a girl named Karin. The story tells his daily life with all of his friend, such as Ponta the puppy, Kuro the wild cat, Rudolph the police dog, Yamada the hamster, and many more!

Puku Puku Tennen Kairanban won the Shogakukan Manga Award for children's manga.